γδ T cells as critical anti-tumor immune effectors
M Arias-Badia, R Chang, L Fong - Nature Cancer, 2024 - nature.com
While the effector cells that mediate anti-tumor immunity have historically been attributed to
αβ T cells and natural killer cells, γδ T cells are now being recognized as a complementary …
αβ T cells and natural killer cells, γδ T cells are now being recognized as a complementary …
A Ménage à trois: NLRC5, immunity, and metabolism
F Brunschwiler, S Nakka, J Guerra… - Frontiers in …, 2024 - frontiersin.org
The nucleotide-binding and oligomerization domain-like receptors (NLRs) NLR family
CARD domain-containing protein 5 (NLRC5) and Class II Major Histocompatibility Complex …
CARD domain-containing protein 5 (NLRC5) and Class II Major Histocompatibility Complex …
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however,
how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of …
how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of …
Structures of human γδ T cell receptor–CD3 complex
W Xin, B Huang, X Chi, Y Liu, M Xu, Y Zhang, X Li… - Nature, 2024 - nature.com
Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune
responses and immunopathology1-3. The γδ T cell receptor (TCR), generated by γδ T cells …
responses and immunopathology1-3. The γδ T cell receptor (TCR), generated by γδ T cells …
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
X Chen, H Zhao, C Wang, M Hamed, Q Shang… - International Journal of …, 2024 - Elsevier
In a vast majority of bacteria, protozoa and plants, the methylerythritol phosphate (MEP)
pathway is utilized for the synthesis of isopentenyl diphosphate (IDP) and dimethylallyl …
pathway is utilized for the synthesis of isopentenyl diphosphate (IDP) and dimethylallyl …
Novel insights into regulation of butyrophilin molecules: critical components of cancer immunosurveillance by γδ T cells
D Kabelitz - Cellular & Molecular Immunology, 2024 - nature.com
Members of the butyrophilin (BTN) family of transmembrane molecules play an important
role in the activation of human γδ T cells. In recent years, it has been discovered that …
role in the activation of human γδ T cells. In recent years, it has been discovered that …
Enhanced Plasma Stability and Potency of Aryl/Acyloxy Prodrugs of a BTN3A1 Ligand
U Singh, G Pawge, S Rani, CHC Hsiao… - ACS medicinal …, 2024 - ACS Publications
While ester-based phosphonate prodrugs excel at delivering payloads into cells, their
instability in plasma is a hurdle for their advancement. Here, we synthesized new …
instability in plasma is a hurdle for their advancement. Here, we synthesized new …
The Evolving Portrait of γδ TCR Recognition Determinants
CL Sok, J Rossjohn, BS Gully - The Journal of Immunology, 2024 - journals.aai.org
In αβ T cells, immunosurveillance is enabled by the αβ TCR, which corecognizes peptide,
lipid, or small-molecule Ags presented by MHC-and MHC class I–like Ag-presenting …
lipid, or small-molecule Ags presented by MHC-and MHC class I–like Ag-presenting …
The potential of γδ CAR and TRuC T cells: An unearthed treasure
WW Schamel, M Zintchenko, T Nguyen… - European Journal of …, 2024 - Wiley Online Library
Recent years have witnessed the success of αβ T cells engineered to express chimeric
antigen receptors (CARs) in treating haematological cancers. CARs combine the tumour …
antigen receptors (CARs) in treating haematological cancers. CARs combine the tumour …
Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1
Phosphoantigens (pAgs) induce conformational changes after binding to the intracellular
region of BTN3A1 which result in its clustering with BTN2A1, forming an activating ligand for …
region of BTN3A1 which result in its clustering with BTN2A1, forming an activating ligand for …