The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Highlights•De novo anticancer drug discovery is challenging and repurposing in oncology is
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …

Chemotherapeutic regimens are the most common treatment to inhibit tumor growth, but
there is great variability in clinical responses of cancer patients; cancer cells often develop …

The nonsteroidal anti‐inflammatory agent aspirin is widely used for preventing and treating
cardiovascular and cerebrovascular diseases. In addition, epidemiologic evidences reveal …

Abstract Purpose of Review Since epidemiological studies first demonstrated a potential
positive effect of metformin in reducing cancer incidence and mortality, there has been an …

Abstract Background Prostate cancer (PCa) is characterized as the most frequent type of
cancer in males. Recent research has suggested patients who have diabetes mellitus taking …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Pancreatic ductal adenocarcinoma continues to be a lethal disease, for which efficient
treatment options are very limited. Increasing efforts have been taken to understand how to …

Metformin (MTF) is a natural compound derived from the legume Galega officinalis. It is the
first line antidiabetic drug for type 2 diabetes (T2D) treatment. One of its main antidiabetic …