Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Natural killer (NK) cell-based immunotherapy represents a promising strategy to overcome
the bottlenecks of cancer treatment. However, the therapeutic efficacy is greatly limited by …

Over the last 60 years an eclectic collection of microbes has been tested in a variety of pre-
clinical models as anti-cancer agents. At the forefront of this research are a number of virus …

As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer
efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for …

Redox regulation has been proposed to control various aspects of carcinogenesis, cancer
cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As …

Despite advances in treatment regimens that comprise surgery, chemotherapy, and
radiation, outcome of many brain tumors remains dismal, more so when they recur. The …

Natural killer (NK) cells-based therapy has been used widely for cancer treatment in clinic
trails. However, the immunotherapeutic efficacy of this method has been greatly hindered by …

Background Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes
oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. With the …

Highlights•Oncolytic viruses (OVs) elicit innate and adaptive immune responses against
tumors.•Although the immune system can react against OVs, a functional immune system is …