Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed

M Feldmann, RN Maini, JN Woody, ST Holgate… - The Lancet, 2020 - thelancet.com
With more than 81 000 deaths worldwide from coronavirus disease 2019 (COVID-19) by
April 8, 2020, 1 it is incumbent on researchers to accelerate clinical trials of any readily …

Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis

YJ Lin, M Anzaghe, S Schülke - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

[HTML][HTML] Targeting TNF-α for COVID-19: recent advanced and controversies

Y Guo, K Hu, Y Li, C Lu, K Ling, C Cai… - Frontiers in public …, 2022 - frontiersin.org
Recent advances in the pathophysiologic understanding of coronavirus disease 2019
(COVID-19) suggests that cytokine release syndrome (CRS) has an association with the …

Pathogenetic insights from the treatment of rheumatoid arthritis

IB McInnes, G Schett - The Lancet, 2017 - thelancet.com
Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular
damage, functional loss, and comorbidity. The development of effective biologics and small …

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

P Raggi, J Genest, JT Giles, KJ Rayner, G Dwivedi… - Atherosclerosis, 2018 - Elsevier
Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …

The role of tumor inflammatory microenvironment in lung cancer

Z Tan, H Xue, Y Sun, C Zhang, Y Song… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is the most common and fatal malignant tumor in the world. The tumor
microenvironment (TME) is closely related to the occurrence and development of lung …

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

B Dinda, S Dinda, S DasSharma, R Banik… - European journal of …, 2017 - Elsevier
Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection: a scoping review

F Infusino, M Marazzato, M Mancone, F Fedele… - Nutrients, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a
devastating event that is causing thousands of victims every day around the world. One of …