Tropane alkaloids (TAs) are among the most valued chemical compounds known since pre-
historic times. Poisonous plants from Solanaceae family (Hyoscyamus niger, Datura, Atropa …

Background Anticholinergic drugs are commonly prescribed, especially to older adults.
Anticholinergic burden scales (ABS) have been used to evaluate the cumulative effects of …

The increase in life expectancy has also been accompanied by an increase in the use of
medication to treat chronic diseases. Polypharmacy is associated with medication-related …

The integration of pharmacotherapy with psychosocial interventions has an important role to
play in the improvement of functional outcome of subjects with schizophrenia (SCZ), in all …

There is evidence that use of drugs with anticholinergic properties increases the risk of
cognitive impairment, and increased exposure to these drugs potentiates this risk …

Purpose The cumulative effect of medication inhibiting acetylcholine activity—also known as
anticholinergic burden (AB)—can lead to functional and cognitive decline, falls, and death …

Introduction Anticholinergic medications are effective for a wide variety of indications, but are
associated with significant central adverse effects, especially cognitive decline and …

Background: Anticholinergic adverse effects pose a relevant threat to patients, in particular
elderly and cognitively impaired patients. Patients with Parkinsonian syndromes are …

Introduction Cognitive impairment (CI) is known to be mediated by several risk and
protective factors, many of which are potentially modifiable. Therefore, it is important to have …

Background Considering the vulnerability of older adults to adverse drug reactions,
medications with strong anticholinergic properties are considered potentially inappropriate …