Biosynthesis of pyrroloindoline-containing natural products

C Sun, W Tian, Z Lin, X Qu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Pyrroloindoline is a privileged tricyclic indoline motif widely present in
many biologically active and medicinally valuable natural products. Thus, understanding the …

Heteroatom–heteroatom bond formation in natural product biosynthesis

AJ Waldman, TL Ng, P Wang, EP Balskus - Chemical reviews, 2017 - ACS Publications
Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

Strategies for engineering natural product biosynthesis in fungi

E Skellam - Trends in Biotechnology, 2019 - cell.com
Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …

Applications of marine-derived microorganisms and their enzymes in biocatalysis and biotransformation, the underexplored potentials

WG Birolli, RN Lima, ALM Porto - Frontiers in microbiology, 2019 - frontiersin.org
Biodiversity has been explored in the search for novel enzymes, including forests, savannas,
tundras, deserts, and finally the sea. Marine microorganisms and their enzymes are capable …

Molecular dynamics simulations guide chimeragenesis and engineered control of chemoselectivity in diketopiperazine dimerases

VV Shende, NR Harris, JN Sanders… - Angewandte Chemie …, 2023 - Wiley Online Library
In the biosynthesis of the tryptophan‐linked dimeric diketopiperazines (DKPs), cytochromes
P450 selectively couple DKP monomers to generate a variety of intricate and isomeric …

New frontiers in flavin-dependent monooxygenases

RAG Reis, H Li, M Johnson, P Sobrado - Archives of Biochemistry and …, 2021 - Elsevier
Flavin-dependent monooxygenases catalyze a wide variety of redox reactions in important
biological processes and are responsible for the synthesis of highly complex natural …

Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo [2.2. 2] diazaoctane ring system from marine and terrestrial fungi

KR Klas, H Kato, JC Frisvad, F Yu… - Natural product …, 2018 - pubs.rsc.org
Covering: up to February 2017 Various fungi of the genera Aspergillus, Penicillium, and
Malbranchea produce prenylated indole alkaloids possessing a bicyclo [2.2. 2] diazaoctane …

The optical nonlinear properties of a new synthesized azo-nitrone compound

DZ Mutlaq, QMA Hassan, HA Sultan, CA Emshary - Optical Materials, 2021 - Elsevier
In this article the preparation of compound heterogeneous azo-nitrone is introduced. Novel
compound resulted via the reaction between azoaldehyde and N-phenylhydroxylamine …

[图书][B] Progress in the chemistry of organic natural products

AD Kinghorn, H Falk, S Gibbons, Y Asakawa, JK Liu… - 2021 - Springer
Termites (Isoptera), which are a suborder of the cockroaches, are the oldest eusocial insects
[1–3]. It is assumed that they diverged from the Cryptocercoidae, woodfeeding cockroaches …

Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine

D Yan, K Wang, S Bai, B Liu, J Bai, X Qi… - Journal of the American …, 2022 - ACS Publications
The [1, 2]-Meisenheimer rearrangement is well known as the [1, 2]-migration of an O-
substituted hydroxylamine from a tertiary amine N-oxide, and it is frequently employed in …