Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Intellectual disability (ID) corresponds to several neurodevelopmental disorders of
heterogeneous origin in which cognitive deficits are commonly associated with …

Tissue-specific mechanisms prompting obesity-related development complications in
humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and …

Early identification of coronary atherosclerotic pathogenic mechanisms is useful for
predicting the risk of coronary heart disease (CHD) and future cardiac events. Epigenome …

Background Individuals with transition from metabolically healthy overweight/obese (MHO)
to metabolically unhealthy overweight/obese (MUO) phenotype are significantly …

Obesity may not be consistently associated with metabolic disorders and mortality later in
life, prompting exploration of the challenging concept of healthy obesity. Here, the …

Extracellular matrix (ECM) remodeling plays important roles in both white adipose tissue
(WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes …

Many empirical networks originate from correlational data, arising in domains as diverse as
psychology, neuroscience, genomics, microbiology, finance, and climate science …

Obese individuals can be categorized as “healthy obese”(MHO) and “unhealthy
obese”(MUO) based on the presence or absence of metabolic abnormality. This study sets …

Obesity has become a worldwide pandemic as well as a major contributing factor to the
increasing rate of type 2 diabetes (T2D). However, there is an intriguing variance …