Bile acids are cholesterol-derived steroid molecules that serve various metabolic functions,
particularly in the digestion of lipids. Gut microbes produce unconjugated and secondary …

Bile acids have important roles in the regulation of lipid, glucose and energy metabolism.
Metabolic diseases linked to obesity, including type 2 diabetes mellitus and non-alcoholic …

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI)
disorders. Determining its mechanistic role in disease has been difficult due to apparent …

Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in
metabolic fuel utilization that elevates circulating ketone bodies; however, the …

Diet is a major factor that shapes the gut microbiome, but the consequences of diet-induced
changes in the microbiome for host pathophysiology remain poorly understood. We …

Background Immune checkpoint inhibitors (ICIs) are promising agents for unresectable
hepatocellular carcinoma (uHCC), but lack effective biomarker to predict outcomes. The gut …

Objective It is evident that the gut microbiota and factors that influence its composition and
activity effect human metabolic, immunological and developmental processes. We …

Background & Aims Studies in mice have shown that the intestinal microbiota can contribute
to obesity via the anorexigenic gut hormone glucagon-like peptide 1 (GLP1) and bile acids …

Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides
difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile …