N-methyl-d-aspartate receptor (NMDAR) antagonists, including ketamine and nitrous oxide,
are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of …

It is well recognized that voltage‐gated calcium (Ca2+) channels modulate the function of
peripheral and central pain pathways by influencing fast synaptic transmission and neuronal …

Several agents that are preferential T-type calcium (T-channel) blockers have shown
promise as being effective in alleviating acute and chronic pain, suggesting an urgent need …

Early exposure to general anesthesia (GA) causes developmental neuroapoptosis in the
mammalian brain and long-term cognitive impairment. Recent evidence suggests that GA …

Nitrous oxide is a widely used analgesic agent, used also in combination with anaesthetics
during surgery. Recent research has raised concerns about possible neurotoxicity of nitrous …

Previous behavioral studies have revealed that Ca V 3.2 T-type calcium channels support
peripheral nociceptive transmission and electrophysiological studies have established the …

The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …

Introduction For a drug that has been omnipresent for nearly 200 years, nitrous oxide's
(N2O) future seems less certain than its illustrious past. Environmental concerns are coming …

This review summarizes recent advances in our understanding of neuronal T–type calcium
channel regulation as well as their physiological and pathophysiological roles. Through their …

Major depressive disorder (MDD) remains a huge personal and societal encumbrance.
Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression …