Comprehensive analysis of intramolecular G-quadruplex structures: furthering the understanding of their formalism
M Farag, L Mouawad - Nucleic Acids Research, 2024 - academic.oup.com
Abstract G-quadruplexes (G4) are helical structures found in guanine-rich DNA or RNA
sequences. Generally, their formalism is based on a few dozen structures, which can …
sequences. Generally, their formalism is based on a few dozen structures, which can …
Molecular crowding promotes the aggregation of parallel structured G-quadruplexes
C Gao, J Deng, N Anwar, M Umer, J Chen, Q Wu… - International Journal of …, 2023 - Elsevier
G-quadruplexes are widely distributed in cells and are usually essential in mediating
biological processes. The intracellular environment is often in a state of molecular crowding …
biological processes. The intracellular environment is often in a state of molecular crowding …
Towards profiling of the G-quadruplex targeting drugs in the living human cells using NMR spectroscopy
D Krafčík, E Ištvánková, Š Džatko, P Víšková… - International Journal of …, 2021 - mdpi.com
Recently, the 1H-detected in-cell NMR spectroscopy has emerged as a unique tool allowing
the characterization of interactions between nucleic acid-based targets and drug-like …
the characterization of interactions between nucleic acid-based targets and drug-like …
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease
R Ishikawa, M Yasuda, S Sasaki, Y Ma… - Chemical …, 2021 - pubs.rsc.org
The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4
ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 …
ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 …
Regulation of thrombin activity by ligand-induced topological alteration in a thrombin-binding aptamer
S Sasaki, Y Ma, T Hirokawa, K Ikebukuro… - Chemical …, 2023 - pubs.rsc.org
Thrombin-binding aptamer (TBA), which forms a G-quadruplex (G4) structure with anti-
parallel topology, interacts with thrombin to inhibit its enzymatic activity. Here we show that …
parallel topology, interacts with thrombin to inhibit its enzymatic activity. Here we show that …
Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs
Y Ma, K Iida, K Nagasawa - Handbook of Chemical Biology of Nucleic …, 2023 - Springer
The various functions of G-quadruplexes (G4s) are starting to emerge with the development
of G4 ligands, which possess selective and strong interacting ability with G4. To achieve the …
of G4 ligands, which possess selective and strong interacting ability with G4. To achieve the …
TARGETING G-QUADRUPLEX DNA: SYNTHESIS OF NEW LIGANDS GUIDED BY ESI MASS SPECTROMETRY AND COMPUTATIONAL METHODS
A Ongaro - 2022 - iris.unibs.it
The search for novel molecules able to bind to the double strand DNA is an important topic
in the medicinal chemistry field and could help therefore to expand the set of drugs used …
in the medicinal chemistry field and could help therefore to expand the set of drugs used …