H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

Hypoxia is the major influence factor in physiological and pathological courses which are
mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions …

CCCTC binding factor (CTCF) is an important factor in the maintenance of chromatin–
chromatin interactions, yet the mechanism regulating its binding to chromatin is unknown …

The human nucleosome acetyltransferase of histone H4 (NuA4)/Tat-interactive protein, 60
kilodalton (TIP60) coactivator complex, a fusion of the yeast switch/sucrose nonfermentable …

Multi-UTR genes are widely transcribed and express their alternative 3′ UTR isoforms in a
cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we …

Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …

During the emergence and radiation of complex multicellular eukaryotes from unicellular
ancestors, transcriptional systems evolved by becoming more complex to provide the basis …

Full activation of the NLRP3 inflammasome needs two sequential signals: a priming signal,
followed by a second, assembly signal. Several studies have shown that the two signals …

High levels of H2A. Z promote melanoma cell proliferation and correlate with poor
prognosis. However, the role of the two distinct H2A. Z histone chaperone complexes …

Simple Summary Individualized medicine means understanding how each tumor is different
from normal cells and how each tumor is different from other tumors, including profiling …