Advances in the characterization of RNA‐binding proteins

D Marchese, NS de Groot… - Wiley …, 2016 - Wiley Online Library
From transcription, to transport, storage, and translation, RNA depends on association with
different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and …

[HTML][HTML] MicroRNA-34 family in breast cancer: from research to therapeutic potential

S Imani, RC Wu, J Fu - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
Abstract MicroRNA (miRNA)-34 family (miR-34s), including miR-34a/b/c, is the most well
studied non-coding RNAs that regulate gene expression post-transcriptionally. The miR-34s …

Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus …

M Guo, X Li, W Tao, F Teng, C Li - Plos Pathogens, 2024 - journals.plos.org
Circular RNAs (circRNAs) are involved in various physiological and pathological processes
in both vertebrates and invertebrates. However, most studies on circRNAs have focused on …

cc SOL omics : a webserver for solubility prediction of endogenous and heterologous expression in Escherichia coli

F Agostini, D Cirillo, CM Livi, R Delli Ponti… - …, 2014 - academic.oup.com
Here we introduce cc SOL omics, a webserver for large-scale calculations of protein
solubility. Our method allows (i) proteome-wide predictions;(ii) identification of soluble …

BindUP: a web server for non-homology-based prediction of DNA and RNA binding proteins

I Paz, E Kligun, B Bengad… - Nucleic acids …, 2016 - academic.oup.com
Gene expression is a multi-step process involving many layers of regulation. The main
regulators of the pathway are DNA and RNA binding proteins. While over the years, a large …

Discovering the 3′ UTR-mediated regulation of alpha-synuclein

D Marchese, T Botta-Orfila, D Cirillo… - Nucleic Acids …, 2017 - academic.oup.com
Recent evidence indicates a link between Parkinson's Disease (PD) and the expression of a-
synuclein (SNCA) isoforms with different 3′ untranslated regions (3′ UTRs). Yet, the post …

Function and regulation of phase-separated biological condensates

XH Li, PL Chavali, R Pancsa, S Chavali, MM Babu - Biochemistry, 2018 - ACS Publications
Achieving functional specificity while minimizing cost to fitness is a key constraint during
evolution. Formation of biological condensates by liquid–liquid phase separation (LLPS) …

LncRNA AC105942. 1 downregulates hnRNPA2/B1 to attenuate vascular smooth muscle cells proliferation

RY Zhang, CM Wu, XM Hu, XM Lin, YN Hua… - DNA and Cell …, 2021 - liebertpub.com
The abnormal proliferation of vascular smooth muscle cells (VSMCs) is crucial in the
atherosclerosis. Although long noncoding RNAs (lncRNAs) are implicated in a variety of …

Post-transcriptional regulatory patterns revealed by protein-RNA interactions

A Zanzoni, L Spinelli, DM Ribeiro, GG Tartaglia… - Scientific Reports, 2019 - nature.com
The coordination of the synthesis of functionally-related proteins can be achieved at the post-
transcriptional level by the action of common regulatory molecules, such as RNA–binding …

In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome

SN Haify, T Botta-Orfila, RK Hukema… - Frontiers in Molecular …, 2020 - frontiersin.org
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative
monogenetic disorder affecting carriers of premutation (PM) forms of the FMR1 gene …