Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

N Greiner, B Barra, G Schiavone, H Lorach… - Nature …, 2021 - nature.com
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor
control in animals and humans with spinal cord injury (SCI). Upper-limb motor control …

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

B Barra, S Conti, MG Perich, K Zhuang… - Nature …, 2022 - nature.com
Regaining arm control is a top priority for people with paralysis. Unfortunately, the
complexity of the neural mechanisms underlying arm control has limited the effectiveness of …

Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates

M Badi, S Wurth, I Scarpato, E Roussinova… - Science Translational …, 2021 - science.org
Restoring dexterous hand control is critical for people with paralysis. Approaches based on
surface or intramuscular stimulation provide limited finger control, generate insufficient force …

Motor cortical dynamics are shaped by multiple distinct subspaces during naturalistic behavior

MG Perich, S Conti, M Badi, A Bogaard, B Barra… - BioRxiv, 2020 - biorxiv.org
Behavior relies on continuous influx of sensory information about the body and the
environment. In primates, cortex integrates somatic feedback to accurately reach and …

Decoding hand kinetics and kinematics using somatosensory cortex activity in active and passive movement

A Mirfathollahi, MT Ghodrati, V Shalchyan… - Iscience, 2023 - cell.com
Area 2 of the primary somatosensory cortex (S1), encodes proprioceptive information of
limbs. Several studies investigated the encoding of movement parameters in this area …

An investigation of manifold-based direct control for a brain-to-body neural bypass

E Losanno, M Badi, E Roussinova… - IEEE Open Journal …, 2024 - ieeexplore.ieee.org
Objective: Brain-body interfaces (BBIs) have emerged as a very promising solution for
restoring voluntary hand control in people with upper-limb paralysis. The BBI module …

Bayesian optimization of peripheral intraneural stimulation protocols to evoke distal limb movements

E Losanno, M Badi, S Wurth… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Motor neuroprostheses require the identification of stimulation protocols that
effectively produce desired movements. Manual search for these protocols can be very time …

Spatiotemporal maps of proprioceptive inputs to the cervical spinal cord during three-dimensional reaching and grasping

P Kibleur, SR Tata, N Greiner, S Conti… - … on Neural Systems …, 2020 - ieeexplore.ieee.org
Proprioceptive feedback is a critical component of voluntary movement planning and
execution. Neuroprosthetic technologies aiming at restoring movement must interact with it …

Validation of manifold-based direct control for a brain-to-body neural bypass

E Losanno, M Badi, E Roussinova, A Bogaard… - bioRxiv, 2022 - biorxiv.org
Brain-body interfaces (BBIs) are neuroprostheses that can restore the connection between
brain activity and body movements. They have emerged as a radical solution for restoring …

Electrical stimulation of the cervical dorsal roots enables functional arm and hand movements in monkeys with cervical spinal cord injury

B Barra, S Conti, MG Perich, K Zhuang, G Schiavone… - Biorxiv, 2020 - biorxiv.org
Regaining arm motor control is a high priority for people with cervical spinal cord injury.
Unfortunately, no therapy can reverse upper limb paralysis. Promising neurotechnologies …