Erythrocytes regulate vascular function through the modulation of oxygen delivery and the
scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell …

The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …

There are numerous reference equations available for the single-breath transfer factor of the
lung for carbon monoxide (T LCO); however, it is not always clear which reference set …

Extracellular vesicles (EVs) are small, double membrane vesicles derived from leukocytes,
platelets, and cells of other tissues under physiological or pathological conditions …

Many diseases are associated with oxidative stress, which occurs when the production of
reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we …

Background Intravascular hemolysis occurs after blood transfusion, in hemolytic anemias,
and in other conditions, and is associated with hypercoagulable states. Hemolysis has been …

Diffusing capacity of the lung for nitric oxide (D LNO), otherwise known as the transfer factor,
was first measured in 1983. This document standardises the technique and application of …

The rate that hemoglobin reacts with nitric oxide (NO) is limited by how fast NO can diffuse
into the heme pocket. The reaction is as fast as any ligand/protein reaction can be and the …

Polymerization of deoxy sickle cell hemoglobin (HbS) is well recognized as the primary
event that triggers the classic cycles of sickling/unsickling of patients red blood cells (RBCs) …

Significance: Cytoglobin (Cygb) was discovered as a new addition to the globin superfamily
and subsequently identified to have potent nitric oxide (NO) dioxygenase function. Cygb …