The selective demethylation of aryl methyl ethers is a reaction of high relevance both in the
context of deprotection in organic syntheses as well as in the modification of lignin and lignin …

Cytochrome P450 monooxygenases (CYPs) are biocatalysts able to catalyze a variety of
regio-and stereoselective oxyfunctionalization reactions using an iron (IV)-oxo porphyrin pi …

Cytochrome P450 enzymes (CYPs) are biocatalysts for the generation of fine chemicals
including natural products, drug metabolites, and flavor and fragrance compounds …

A highly sought after reaction in chemical synthesis is the activation of unactivated carbon–
hydrogen bonds. We demonstrate the hydroxylation of fatty acids using an engineered …

Low lignin solubility in aqueous solution is one of the major bottlenecks for lignin
biodegradation and bioconversion. Alkaline solution contributes to improving lignin …

Using machine learning, molecular dynamics simulations, and density functional theory
calculations we gain insight into the selectivity patterns of substrate activation by the …

A crucial reaction in chemical synthesis is the activation of unactivated carbon–hydrogen
bonds in complex molecules. We demonstrate the regio-and stereo-selective hydroxlation of …

Selective C (sp 3)–H bond activation and functionalization into a C–N bond has been one of
the major challenges facing the pharmaceutical and fine chemical industries. Being the …

The cytochrome P450 monooxygenases (CYPs) are a class of heme‐thiolate enzymes that
insert oxygen into unactivated C− H bonds. These enzymes can be converted into …

The cytochrome P450 enzymes (CYPs) are heme-thiolate monooxygenases that catalyse
the insertion of an oxygen atom into the C–H bonds of organic molecules. In most CYPs, the …