Ca 2+-triggered neurotransmitter release involves complex regulatory mechanisms,
including a series of protein-protein interactions. Three proteins, synaptobrevin (VAMP) …

Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane,
which leads to neurotransmitter release. This exocytosis is triggered by brief and local …

Optical tweezers allow precise measurement of forces and distances with piconewton and
nanometer precision, and have thus been instrumental in elucidating the mechanistic details …

Protein binding to negatively charged lipids is essential for maintaining numerous vital
cellular processes where its dysfunction can lead to various diseases. One such protein that …

Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by
SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE …

Background Pathogenic missense variants in the essential synaptic vesicle protein
synaptotagmin-1 (SYT1) cause a neurodevelopmental disorder characterised by motor …

Neurotransmitters are stored in small membrane-bound vesicles at synapses; a subset of
synaptic vesicles is docked at release sites. Fusion of docked vesicles with the plasma …

Signal transmission between neurons requires exocytosis of neurotransmitters from the
lumen of synaptic vesicles into the synaptic cleft. Following an influx of Ca 2+, this process is …

Protein structure prediction has emerged as a core technology for understanding
biomolecules and their interactions. Here, we combine homology‐based structure prediction …

Missense variants in the presynaptic calcium sensor synaptotagmin-1 (SYT1) are associated
with an autosomal dominant neurodevelopmental disorder (NDD). These cause dominant …