Applications of single-cell RNA sequencing in drug discovery and development

B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Translational opportunities of single-cell biology in atherosclerosis

MPJ De Winther, M Bäck, P Evans… - European heart …, 2023 - academic.oup.com
The advent of single-cell biology opens a new chapter for understanding human biological
processes and for diagnosing, monitoring, and treating disease. This revolution now …

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update

Nucleic Acids Research, 2022 - academic.oup.com
Galaxy is a mature, browser accessible workbench for scientific computing. It enables
scientists to share, analyze and visualize their own data, with minimal technical …

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

E Afgan, D Baker, B Batut, M Van Den Beek… - Nucleic acids …, 2018 - academic.oup.com
Abstract Galaxy (homepage: https://galaxyproject. org, main public server: https://usegalaxy.
org) is a web-based scientific analysis platform used by tens of thousands of scientists …

Expression Atlas update: gene and protein expression in multiple species

P Moreno, S Fexova, N George… - Nucleic acids …, 2022 - academic.oup.com
Abstract The EMBL-EBI Expression Atlas is an added value knowledge base that enables
researchers to answer the question of where (tissue, organism part, developmental stage …

UCSC Cell Browser: visualize your single-cell data

ML Speir, A Bhaduri, NS Markov, P Moreno… - …, 2021 - academic.oup.com
As the use of single-cell technologies has grown, so has the need for tools to explore these
large, complicated datasets. The UCSC Cell Browser is a tool that allows scientists to …

Single-cell multiomics

E Flynn, A Almonte-Loya… - Annual review of …, 2023 - annualreviews.org
Single-cell RNA sequencing methods have led to improved understanding of the
heterogeneity and transcriptomic states present in complex biological systems. Recently, the …

[HTML][HTML] Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5. 1/AS01B malaria vaccine

CM Nielsen, JR Barrett, C Davis, JK Fallon, C Goh… - JCI insight, 2023 - ncbi.nlm.nih.gov
Modifications to vaccine delivery that increase serum antibody longevity are of great interest
for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing …

A roadmap for the human gut cell atlas

M Zilbauer, KR James, M Kaur, S Pott, Z Li… - Nature Reviews …, 2023 - nature.com
The number of studies investigating the human gastrointestinal tract using various single-
cell profiling methods has increased substantially in the past few years. Although this …

Asc-Seurat: analytical single-cell Seurat-based web application

WJ Pereira, FM Almeida, D Conde, KM Balmant… - BMC …, 2021 - Springer
Background Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of
transcriptomes, arising as a powerful tool for discovering and characterizing cell types and …