[HTML][HTML] Polymerase iota-an odd sibling among Y family polymerases
J McIntyre - DNA repair, 2020 - Elsevier
It has been two decades since the discovery of the most mutagenic human DNA
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …
Reactive oxygen species play an important role in the bactericidal activity of quinolone antibiotics
Recent studies posit that reactive oxygen species (ROS) contribute to the cell lethality of
bactericidal antibiotics. However, this conjecture has been challenged and remains …
bactericidal antibiotics. However, this conjecture has been challenged and remains …
Basic, translational and clinical relevance of the DNA repair and redox signaling protein APE1 in human diseases
Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …
Human Y-Family DNA Polymerase κ Is More Tolerant to Changes in Its Active Site Loop than Its Ortholog Escherichia coli DinB
DNA damage is a constant threat and can be bypassed in a process called translesion
synthesis, which is typically carried out by Y-family DNA polymerases. Y-family DNA …
synthesis, which is typically carried out by Y-family DNA polymerases. Y-family DNA …
Site‐Specific N2‐dG DNA Adducts: Formation, Synthesis, and TLS Polymerase‐Mediated Bypass
PP Ghodke, PI Pradeepkumar - European Journal of Organic …, 2020 - Wiley Online Library
The N2‐position of deoxyguanosine (dG) in DNA is susceptible to modification by various
damaging agents. These modifications (lesions or adducts) can stall the DNA replication by …
damaging agents. These modifications (lesions or adducts) can stall the DNA replication by …
Computational insight into the differential mutagenic patterns of O-methylthymine lesions
P Bhutani, DJ Nikkel, KA Wilson… - Chemical Research in …, 2019 - ACS Publications
Differential mutagenic patterns were recently reported for O-methylated thymine lesions,
which indicate that O4-methylthymine (O4-Me-T) frequently leads to G misinsertions …
which indicate that O4-methylthymine (O4-Me-T) frequently leads to G misinsertions …
Computational evaluation of nucleotide insertion opposite expanded and widened DNA by the translesion synthesis polymerase Dpo4
L Albrecht, KA Wilson, SD Wetmore - Molecules, 2016 - mdpi.com
Expanded (x) and widened (y) deoxyribose nucleic acids (DNA) have an extra benzene ring
incorporated either horizontally (xDNA) or vertically (yDNA) between a natural pyrimidine …
incorporated either horizontally (xDNA) or vertically (yDNA) between a natural pyrimidine …
Unique Roles of Human Translesion Synthesis DNA Polymerase η
PP Ghodke, FP Guengerich - 2020 - books.rsc.org
The integrity and stability of genetic information are crucial to life, and therefore, DNA
maintenance is a key factor for cell survival. DNA polymerases (pols) play important roles in …
maintenance is a key factor for cell survival. DNA polymerases (pols) play important roles in …
Replicative and Transcriptional Bypass of Alkylated DNA Lesions in Human Cells
Y Tan, S Guo, Y Wang - 2020 - books.rsc.org
The genomic integrity of human cells is constantly challenged by exposure to DNA
damaging agents that are formed from endogenous metabolism and/or from environmental …
damaging agents that are formed from endogenous metabolism and/or from environmental …
[图书][B] Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
NM Antczak - 2017 - search.proquest.com
DNA damage is a constant threat and can block replication. Y-family DNA polymerases can
replicate damaged DNA through the process of translesion synthesis (TLS). Y-family DNA …
replicate damaged DNA through the process of translesion synthesis (TLS). Y-family DNA …