It has been two decades since the discovery of the most mutagenic human DNA
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …

Recent studies posit that reactive oxygen species (ROS) contribute to the cell lethality of
bactericidal antibiotics. However, this conjecture has been challenged and remains …

Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …

DNA damage is a constant threat and can be bypassed in a process called translesion
synthesis, which is typically carried out by Y-family DNA polymerases. Y-family DNA …

The N2‐position of deoxyguanosine (dG) in DNA is susceptible to modification by various
damaging agents. These modifications (lesions or adducts) can stall the DNA replication by …

Differential mutagenic patterns were recently reported for O-methylated thymine lesions,
which indicate that O4-methylthymine (O4-Me-T) frequently leads to G misinsertions …

Expanded (x) and widened (y) deoxyribose nucleic acids (DNA) have an extra benzene ring
incorporated either horizontally (xDNA) or vertically (yDNA) between a natural pyrimidine …

The integrity and stability of genetic information are crucial to life, and therefore, DNA
maintenance is a key factor for cell survival. DNA polymerases (pols) play important roles in …

The genomic integrity of human cells is constantly challenged by exposure to DNA
damaging agents that are formed from endogenous metabolism and/or from environmental …

DNA damage is a constant threat and can block replication. Y-family DNA polymerases can
replicate damaged DNA through the process of translesion synthesis (TLS). Y-family DNA …