The multifaceted role of ferroptosis in liver disease

J Chen, X Li, C Ge, J Min, F Wang - Cell Death & Differentiation, 2022 - nature.com
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …

Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

The interaction between ferroptosis and inflammatory signaling pathways

Y Chen, ZM Fang, X Yi, X Wei, DS Jiang - Cell death & disease, 2023 - nature.com
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

Z Zhang, J Tang, J Song, M Xie, Y Liu, Z Dong… - Free Radical Biology …, 2022 - Elsevier
Hypertension-mediated pathological cardiac remodeling often progresses to heart failure.
Elabela, mainly expressed in the cardiac microvascular endothelial cells (CMVECs) …

[HTML][HTML] The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

DM Cheff, C Huang, KC Scholzen, R Gencheva… - Redox Biology, 2023 - Elsevier
Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …

Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice

Y Zeng, R Wu, F Wang, S Li, L Li, Y Li, P Qin, M Wei… - Cell Host & Microbe, 2023 - cell.com
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The
impact of the gut microbiota and associated metabolites on APAP and liver function remains …

Molecular mechanisms of ferroptosis and relevance to inflammation

L Deng, S He, N Guo, W Tian, W Zhang, L Luo - Inflammation Research, 2023 - Springer
Introduction Inflammation is a defensive response of the organism to irritation which is
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …

[HTML][HTML] Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model

Z Pei, Y Qin, X Fu, F Yang, F Huo, X Liang, S Wang… - Redox biology, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Z Ni, Y Li, D Song, J Ding, S Mei, S Sun, W Cheng… - Cell death & …, 2022 - nature.com
Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main
causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron …

The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage

N Liu, Y Liang, T Wei, L Zou, X Huang, L Kong… - Journal of Hazardous …, 2022 - Elsevier
Cadmium telluride quantum dots (CdTe QDs) exist in the environment due to the
abandonment of products. There is a potential risk to organisms and toxic mechanism is …