The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …

Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …

Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but
often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid …

Transient receptor potential vanilloid 1 (TRPV1) channels are widely distributed in sensory
nerve endings, the central nervous system, and other tissues, functioning as ion channel …

The vanilloid receptor TRPV1 is an exquisite nociceptive sensor of noxious heat, but its
temperature-sensing mechanism is yet to define. Thermodynamics dictate that this channel …

Although TRPV1 ion channel has been attracting researchers' attention for many years, its
functions in animal organisms, the principles of regulation, and the involvement in …

The transient receptor potential vanilloid type 1 (TRPV1) is a multimodal receptor which
responds to various stimuli, including capsaicin, protons, and heat. Recent advances in cryo …

TRPV1 plays an important role in the thermosensory system; however, the mechanism
controlling its heat activation property is not well understood. Here, we determine the heat …

In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …