Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Hyperactive TLR7 signaling has long been appreciated as driver of autoimmune disease in
mouse models. Recently, gain-of-function mutations in TLR7 were identified as a monogenic …

The transfer of endocytosed cargoes to lysosomes (LYSs) requires HOPS, a multiprotein
complex that tethers late endosomes (LEs) to LYSs before fusion. Many proteins interact …

Exosomes are small vesicles that are secreted from cells to dispose of undegraded
materials and mediate intercellular communication. A major source of exosomes is …

Cholesterol trafficking is initiated by the endocytic pathway and transported from
endo/lysosomes to other intracellular organelles. Deficiencies in cholesterol-sensing and …

The multisubunit HOPS tethering complex is a well-established regulator of lysosome fusion
with late endosomes and autophagosomes. However, the role of the HOPS complex in other …

Cells depend on their endolysosomal system for nutrient uptake and downregulation of
plasma membrane proteins. These processes rely on endosomal maturation, which requires …

Autophagy induction by starvation has been shown to enhance lysosomal delivery to
mycobacterial phagosomes, resulting in the restriction of the Mycobacterium tuberculosis …

BLOC1S1 is a common component of BLOC and BORC multiprotein complexes which play
distinct roles in endosome and lysosome biology. Recent human mutations in BLOC1S1 …

Hyperactive Toll-like receptor (TLR) 7 signaling has long been appreciated as a driver of
autoimmune disease by breaking tolerance to self-nucleic acids in mouse models …