Glioblastoma and other malignant gliomas: a clinical review

A Omuro, LM DeAngelis - Jama, 2013 - jamanetwork.com
Importance Glioblastomas and malignant gliomas are the most common primary malignant
brain tumors, with an annual incidence of 5.26 per 100 000 population or 17 000 new …

Sex-specific differences in glioblastoma

A Carrano, JJ Juarez, D Incontri, A Ibarra, HG Cazares - Cells, 2021 - mdpi.com
Sex differences have been well identified in many brain tumors. Even though glioblastoma
(GBM) is the most common primary malignant brain tumor in adults and has the worst …

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors

DA Wainwright, AL Chang, M Dey, IV Balyasnikova… - Clinical cancer …, 2014 - AACR
Purpose: Glioblastoma (GBM) is the most common form of malignant glioma in adults.
Although protected by both the blood–brain and blood–tumor barriers, GBMs are actively …

The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis

P de Robles, KM Fiest, AD Frolkis, T Pringsheim… - Neuro …, 2015 - academic.oup.com
Background Primary brain tumors are a heterogeneous group of benign and malignant
tumors arising from the brain parenchyma and its surrounding structures. The epidemiology …

Emerging insights into the molecular and cellular basis of glioblastoma

GP Dunn, ML Rinne, J Wykosky… - Genes & …, 2012 - genesdev.cshlp.org
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …

Glioblastoma: from molecular pathology to targeted treatment

TF Cloughesy, WK Cavenee… - Annual review of …, 2014 - annualreviews.org
Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses are
defining the molecular architecture of GBM, uncovering relevant subsets of patients whose …

[HTML][HTML] Epidemiology of glial and non-glial brain tumours in Europe

E Crocetti, A Trama, C Stiller, A Caldarella… - European journal of …, 2012 - Elsevier
To the central nervous system (CNS) belong a heterogeneous group of glial and non glial
rare cancers. The aim of the present study was to estimate the burden (incidence …

The integrated landscape of driver genomic alterations in glioblastoma

V Frattini, V Trifonov, JM Chan, A Castano, M Lia… - Nature …, 2013 - nature.com
Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a
computational platform that integrates the analysis of copy number variations and somatic …

Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer

HJ Butler, PM Brennan, JM Cameron… - Nature …, 2019 - nature.com
Non-specific symptoms, as well as the lack of a cost-effective test to triage patients in primary
care, has resulted in increased time-to-diagnosis and a poor prognosis for brain cancer …

Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets

H Mao, DG LeBrun, J Yang, VF Zhu, M Li - Cancer investigation, 2012 - Taylor & Francis
Glioblastoma multiforme (GBM) is the most malignant and aggressive type of brain tumor
with an average life expectancy of less than 15 months. This is mostly due to the highly …