The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …

An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila
exhibits positive systemic effects on host health, mainly by improving immunological and …

Objective Alzheimer's disease (AD) is a global health problem without effective methods to
alleviate the disease progression. Amyloid β-protein (Aβ) is widely accepted as a key …

Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

The brain is one of the most exquisite organs in the body with high metabolic demands, and
requires a tight regulation of the surrounding environment. This tight control is exerted by the …

Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Abstract DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …

Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two global epidemics that
share several metabolic defects, such as insulin resistance, impaired glucose metabolism …

We aimed to investigate mitochondrial function, biogenesis and autophagy in the brain of
type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and …

Along with the increase in life expectancy over the last century, the prevalence of age-
related disorders, such as neurodegenerative diseases continues to rise. This is the case of …