A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

“One of the deepest, most illuminating books about the history of life to have been published
in recent years.”—The Economist The Earth teems with life: in its oceans, forests, skies and …

SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex
determination. Recent studies in mice reveal that the major role of SRY is to achieve …

Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …

Disorders of sex development (DSD) are congenital conditions in which the development of
chromosomal, gonadal, or anatomical sex is atypical. Many of the genes required for gonad …

Mammalian sex determination hinges on the development of ovaries or testes, with testis
fate being triggered by the expression of the transcription factor sex-determining region Y …

Sex differences in diseases involving oxidative and proteolytic stress are common, including
greater ischemic heart disease, Parkinson disease and stroke in men, and greater …