Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this
Review, we discuss accumulating evidence indicating that type I IFNs produced by …

Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

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Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while
paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the …

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions
and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and-extrinsic …

Myeloproliferative neoplasms (MPNs) arise in the hematopoietic stem cell (HSC)
compartment as a result of the acquisition of somatic mutations in a single HSC that provides …

Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced
by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the …

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders
characterized by activated Janus kinase (JAK)–signal transducer and activator of …