Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Peptide macrocycles have found applications that range from drug discovery to
nanomaterials. These ring-shaped molecules have shown remarkable capacity for …

As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

The last decade has witnessed a renaissance of peptides as drugs. This progress, together
with advances in the structural behavior of peptides, has attracted the interest of the …

Macrocyclic peptides represent promising scaffolds for chemical tools and potential
therapeutics. Synthetic methods for peptide macrocyclization are often hampered by C …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Here, we report a novel “CyClick” strategy for the macrocyclization of peptides that works in
an exclusively intramolecular fashion thereby precluding the formation of dimers and …

Targeted therapies of melanoma are of urgent need considering the resistance of this
aggressive type of cancer to chemotherapeutics. The voltage-dependent anion channel 1 …