The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the
extracellular matrix, is an absolute requirement for the survival of disseminating and …

Resistance of melanoma to targeted therapy and immunotherapy is linked to metabolic
rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF …

Background Multi-faceted evidence from a range of cancers suggests strongly that de novo
expression of voltage-gated sodium channels (VGSCs) plays a significant role in driving …

Whereas it is known that p53 broadly regulates cell metabolism, the specific activities that
mediate this regulation remain partially understood. Here, we identified carnitine o …

Background Lipid droplet formation is a prominent histological feature in clear cell renal cell
carcinoma (ccRCC), but the significance and mechanisms underlying lipid droplet …

Background Glioblastoma (GBM) is an aggressive brain cancer associated with poor
prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell …

Objectives To investigate the importance of fatty acid oxidation (FAO)-related genes in
predicting the progression and prognosis of head and neck squamous cell carcinoma …

We review extensive progress from the cancer metabolism community in understanding the
specific properties of lipid metabolism as it is redesigned in advanced carcinomas. This …

Endoplasmic reticulum (ER) stress exerts significant effects on cell growth, proliferation,
migration, invasion, chemoresistance, and angiogenesis in various cancers. However, the …

Metabolic reprogramming promotes and sustains multiple steps of melanoma metastasis.
Identification of key regulators of metabolic reprogramming could lead to the development of …