The role of the adenosine system in epilepsy and its comorbidities
JA Baltos, PM Casillas‐Espinosa… - British Journal of …, 2024 - Wiley Online Library
Epilepsy is one of the most serious and common chronic neurological conditions,
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …
Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease
FQ Gonçalves, FC Matheus, HB Silva, JI Real… - Molecular …, 2023 - Springer
Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in
Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly …
Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly …
Adenosine A2A receptors control synaptic remodeling in the adult brain
X Xu, RO Beleza, FQ Gonçalves, S Valbuena… - Scientific Reports, 2022 - nature.com
The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …
CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity
AP Simões, FQ Gonçalves, D Rial, SG Ferreira… - International Journal of …, 2022 - mdpi.com
Adenosine A2A receptors (A2AR) control fear memory and the underlying processes of
synaptic plasticity in the amygdala. In other brain regions, A2AR activation is ensured by …
synaptic plasticity in the amygdala. In other brain regions, A2AR activation is ensured by …
Increased synaptic ATP release and CD73-mediated formation of extracellular adenosine in the control of behavioral and electrophysiological modifications caused …
L Dias, D Pochmann, C Lemos, HB Silva… - ACS Chemical …, 2023 - ACS Publications
Increased ATP release and its extracellular catabolism through CD73 (ecto-5′-
nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in …
nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in …
Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy
HY Shen, SB Baer, R Gesese, JM Cook… - Frontiers in …, 2022 - frontiersin.org
Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study
aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of …
aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of …
Brain iron deficiency changes the stoichiometry of adenosine receptor subtypes in cortico-striatal terminals: implications for restless legs syndrome
MS Rodrigues, SG Ferreira, C Quiroz, CJ Earley… - Molecules, 2022 - mdpi.com
Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless
legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS …
legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS …
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
Astrocytes are multi-functional glial cells in the central nervous system that play critical roles
in modulation of metabolism, extracellular ion and neurotransmitter levels, and synaptic …
in modulation of metabolism, extracellular ion and neurotransmitter levels, and synaptic …
Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation
CR Lopes, FQ Gonçalves, S Olaio, AR Tomé… - Biomolecules, 2023 - mdpi.com
Adenosine operates a modulation system fine-tuning the efficiency of synaptic transmission
and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal …
and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal …
Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors
P Xie, S Liu, Q Huang, Z Xiong, J Deng… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims Deep brain stimulation (DBS) of the anterior nucleus of the thalamus, is an effective
therapy for patients with drug‐resistant epilepsy, yet, its mechanism of action remains …
therapy for patients with drug‐resistant epilepsy, yet, its mechanism of action remains …