Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

JG Beeson, DR Drew, MJ Boyle, G Feng… - FEMS microbiology …, 2016 - academic.oup.com
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

Human genetics and malaria resistance

SN Kariuki, TN Williams - Human genetics, 2020 - Springer
Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

J Gruszczyk, U Kanjee, LJ Chan, S Menant, B Malleret… - Science, 2018 - science.org
Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin
receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We …

A research agenda for malaria eradication: vaccines

malERA Consultative Group on Vaccines - PLoS medicine, 2011 - journals.plos.org
Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to
develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed …

The future for blood‐stage vaccines against malaria

JS Richards, JG Beeson - Immunology and cell biology, 2009 - Wiley Online Library
Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …

The immunology of Plasmodium vivax malaria

LR Antonelli, C Junqueira, JM Vinetz… - Immunological …, 2020 - Wiley Online Library
Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

Human genetics of infectious diseases: Unique insights into immunological redundancy

JL Casanova, L Abel - Seminars in immunology, 2018 - Elsevier
For almost any given human-tropic virus, bacterium, fungus, or parasite, the clinical outcome
of primary infection is enormously variable, ranging from asymptomatic to lethal infection …

Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention

JA Rowe, DH Opi, TN Williams - Current opinion in hematology, 2009 - journals.lww.com
Blood groups and malaria: fresh insights into pathogenesis a... : Current Opinion in Hematology
Blood groups and malaria: fresh insights into pathogenesis and identification of targets for …

Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein

TH Dickey, NH Tolia - Trends in parasitology, 2023 - cell.com
Malaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity
against blood-stage infection reduces parasitemia and disease severity. Duffy-binding …

A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax

B Russell, R Suwanarusk, C Borlon… - Blood, The Journal …, 2011 - ashpublications.org
Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines
against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America …