Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Centrosomes are the primary microtubule organizer in eukaryotic cells. In addition to
shaping the intracellular microtubule network and the mitotic spindle, centrosomes are …

The centrosome, consisting of centrioles and the associated pericentriolar material, is the
main microtubule-organizing centre (MTOC) in animal cells. During most of interphase, the …

The centrosome linker joins the two interphase centrosomes of a cell into one microtubule
organizing center. Despite increasing knowledge on linker components, linker diversity in …

An increase in centrosome number is commonly observed in cancer cells, but the role
centrosome amplification plays along with how and when it occurs during cancer …

Whole-genome duplication (WGD) is one of the most common genomic abnormalities in
cancers. WGD can provide a source of redundant genes to buffer the deleterious effect of …

Centrosomes are major organizing components of the tubulin-based cytoskeleton. In recent
years, we have gained extensive knowledge about their structure, biogenesis, and function …

Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular
signalling and motility. Intraflagellar transport (IFT) contributes to the formation of the highly …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a
poor prognosis. More effective biomarkers and treatment options remain to be discovered …

Motile cilia on the cell surface generate movement and directional fluid flow that is crucial for
various biological processes. Dysfunction of these cilia causes human diseases such as …