Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is
usually defined by characteristics of intoxication or by characteristics of withdrawal …

Abstract Background In May 2018, the Secretariat for the World Health Organization
Framework Convention on Tobacco Control convened a meeting to discuss the potential for …

Tobacco smoking is reputed to be the most difficult addiction of all to give up, and nicotine
has been noted as the major addictive agent in tobacco smoke. However, research shows …

The World Health Organization was established in 1948 as a specialized agency of the
United Nations serving as the directing and coordinating authority for international health …

The aim of the current study was to determine whether non-nicotine constituents of cigarette
smoke contribute to nicotine dependence in adolescent and adult male Sprague Dawley …

Monoamine oxidase (MAO) activity is reduced in cigarette smokers and this may promote
the reinforcing actions of nicotine, thereby enhancing the addictive properties of cigarettes …

Nicotine is the primary addictive component in cigarette smoke, and dopamine release
induced by nicotine is considered a significant cause of persistent smoking and nicotine …

Large reductions in nicotine content could dramatically reduce reinforcement from and
dependence on cigarettes. In this article, we summarise the potential benefits of reducing …

The use of cigarettes delivering different nicotine doses allows evaluation of the contribution
of nicotine to the smoking experience. We compared responses of 46 young adult smokers …

Background and aims Monoamine oxidase inhibitors have been hypothesised to be
important in tobacco dependence, reinforcing the brain's response to nicotine by delaying …