One of the great challenges for molecular biologists is to learn how a protein sequence
defines its three-dimensional structure. For many years, the problem was even more difficult …

Biological membranes are characterized by a heterogeneous composition, which is not only
manifested in the wide variety of their components, but also in aspects like the lateral …

Cationic antimicrobial peptides (CAPs) occur as important innate immunity agents in many
organisms, including humans, and offer a viable alternative to conventional antibiotics, as …

The hydrophobicity (H), hydrophobic moment (μ) and the angle subtended by the positively
charged helix face (Φ) of a set of model and magainin2amide peptides with conserved …

The MICs of cationic, hydrophobic peptides of the prototypic sequence
KKAAAXAAAAAXAAWAAXAAAKKKK-amide (where X is one of the 20 commonly occurring …

The molecular forces that stabilize membrane protein structure are poorly understood. To
investigate these forces we introduced alanine substitutions at 24 positions in the B helix of …

Integral membrane proteins are embedded in a watersolvated lipid bilayer that presents
contrasting features in an anisotropic, chemically heterogeneous environment. A …

α-Helix formation in globular proteins has been studied both theoretically and
experimentally for decades, while a lack of both high-resolution structures and suitable …

Model compounds of modified hydrophobicity (H), hydrophobic moment (μ) and angle
subtended by charged residues (Φ) were synthesized to define the general roles of …

The large number of sequences available for the aquaporin family represents a valuable
source of information to incorporate into three-dimensional structure determination …