Diabetic nephropathy is one of the most prevalent microvascular complication in patients
suffering from diabetes and is reported to be the major cause of renal failure when …

Abstract Currently, 5.4 million Americans suffer from AD, and these numbers are expected to
increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have …

Abstract miRWalk (http://mirwalk. uni-hd. de/) is a publicly available comprehensive
resource, hosting the predicted as well as the experimentally validated microRNA (miRNA) …

Background Patients heterozygous for COL4A3 or COL4A4 mutations show a wide
spectrum of disease, extending from familial isolated microscopic haematuria, as a result of …

Diabetic nephropathy is the most common cause of chronic kidney failure and end-stage
renal disease in the Western World. One of the major characteristics of this disease is the …

Digenic inheritance (DI) concerns pathologies with the simplest form of multigenic etiology,
implicating more than 1 gene (and perhaps the environment). True DI is when biallelic or …

Abstract hTERT is the catalytic subunit of the telomerase complex. Elevated expression of
hTERT is associated with the expansion and metastasis of gastric tumor. In this study, we …

Aging is a normal process of living being. It has been reported that multiple cellular changes,
including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation …

MicroRNAs (miRNAs) comprise a recently discovered class of small, non-coding RNA
molecules of 21-25 nucleotides in length that regulate the gene expression by base-pairing …

A recent genome–wide association study of IgA nephropathy (IgAN) identified 1q32, which
contains multiple complement regulatory genes, including the complement factor H (CFH) …