E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

Epidermal growth factor receptor (EGFR) is highly expressed in certain cancer types and is
involved in regulating the biological characteristics of cancer progression, including …

MAVS and MITA are essential adaptor proteins mediating innate antiviral immune
responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays …

A convenient and practical strategy was developed for the synthesis of carbamo
(dithioperoxo) thioates through the simple dehydrogenation coupling of thiols and amines …

Accumulating evidence suggests that E3 ubiquitin ligases play important roles in cancer
development. In this article, we provide a comprehensive summary of the roles of the Nedd4 …

The zinc-ejecting aldehyde dehydrogenase (ALDH) inhibitory drug disulfiram (DSF) was
found to be a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor …

E3 ubiquitin ligase RNF126 (ring finger protein 126) is highly expressed in various cancers
and strongly associated with tumorigenesis. However, its specific function in bladder cancer …

Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies, and the
incidence of RCC continues to rise worldwide. Although RCC can be treated with surgery at …

The subcellular localization and intracellular trafficking of Toll‐like receptors (TLRs) critically
regulate TLRs‐mediated antimicrobial immunity and autoimmunity. Here, it is demonstrated …

This paper reports the synthesis of compounds formed by two indole systems separated by a
heterocycle (pyridine or piperazine). As a primary screening, the new compounds were …