Anti‐cancer therapies targeting and damaging the DNA have been extensively used in the
last 50 years since the discovery of nitrogen mustards, antimetabolites and platin agents …

Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and
extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not …

Cancers have dysfunctional redox regulation resulting in reactive oxygen species
production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized …

Activated RAS GTPase signalling is a critical driver of oncogenic transformation and
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …

For a little over a decade now, the Macromolecular Crystallography (MX) group at the
Helmholtz-Zentrum Berlin (HZB) has been operating three state-of-the-art synchrotron …

The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as
mRNA processing. Although highly conserved throughout all organisms, their biological …

Plant genomes encode isopentenyl phosphate kinases (IPKs) that reactivate isopentenyl
phosphate (IP) via ATP-dependent phosphorylation, forming the primary metabolite …

Recent literature has claimed that inhibition of the enzyme MTH1 can eradicate cancer.
MTH1 is one of the “housekeeping” enzymes that are responsible for hydrolyzing damaged …

Deregulated redox metabolism in cancer leads to oxidative damage to cellular components
including deoxyribonucleoside triphosphates (dNTPs). Targeting dNTP pool sanitizing …

Most of the proteins carrying the 23-residue MutT-related sequence are capable of
hydrolyzing compounds with a general structure of nucleoside diphosphate linked to …