Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis.
However, their aberrant overexpression and glycosylation in various malignancies facilitate …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

Background Differential expression of mucins has been associated with several cancers
including colorectal cancer (CRC). In normal physiological conditions, secretory mucin …

Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin
cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes …

Background & Aims It is not clear how pancreatic cancer stem cells (CSCs) are regulated,
resulting in ineffective treatments for pancreatic cancer. PAF1, a RNA polymerase II …

Lung cancer is the leading cause of cancer-related death worldwide, yet in vitro disease
models have been limited to traditional 2D culture utilizing cancer cell lines. In contrast …

Background Colon cancer (CC) is the second most common gastrointestinal malignancy.
About one in five patients have already developed distant metastases at the time of initial …

Purpose: MUC16, a tumor biomarker and cell surface–associated mucin, is overexpressed
in various cancers; however, its role in lung cancer pathogenesis is unknown. Here, we …

Overexpression of mucin glycoproteins has been demonstrated in many epithelial-derived
cancers. The significance of this overexpression remains uncertain. The aim of this paper …