The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …

Recently, increasing evidence has suggested the association between gut dysbiosis and
Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis …

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

B cells represent a relatively minor cell population within both the healthy and diseased
central nervous system (CNS), yet they can have profound effects. This is emphasized in …

The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings
suggest that these CNS-associated border tissues have complex immunological functions …