Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
HIV “shock and kill” therapy: In need of revision
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …
clinically manageable. However, the disease remains incurable, since it establishes latent …
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
CRISPR/Cas9 gene editing can inactivate genes in a precise manner. This process involves
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …
Tissue memory relies on stem cell priming in distal undamaged areas
C Levra Levron, M Watanabe, V Proserpio… - Nature Cell …, 2023 - nature.com
Epithelial cells that participated in wound repair elicit a more efficient response to future
injuries, which is believed to be locally restricted. Here we show that cell adaptation …
injuries, which is believed to be locally restricted. Here we show that cell adaptation …
Pharmacological targeting of the cancer epigenome
Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …
disease initiation, maintenance and therapy resistance. As a result, there have been …
Histone deacetylase inhibitors and phenotypical transformation of cancer cells
A Wawruszak, J Kalafut, E Okon, J Czapinski, M Halasa… - Cancers, 2019 - mdpi.com
Histone deacetylase inhibitors (HDIs) are a group of potent epigenetic drugs which have
been investigated for their therapeutic potential in various clinical disorders, including …
been investigated for their therapeutic potential in various clinical disorders, including …
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
Genomic DNA is folded into a higher-order structure that regulates transcription and
maintains genomic stability. Although progress has been made on understanding …
maintains genomic stability. Although progress has been made on understanding …
Scales and mechanisms of somatic mutation rate variation across the human genome
Cancer genome sequencing has revealed that somatic mutation rates vary substantially
across the human genome and at scales from megabase-sized domains to individual …
across the human genome and at scales from megabase-sized domains to individual …
[HTML][HTML] Identification and experimental validation of druggable epigenetic targets in hepatoblastoma
A Clavería-Cabello, JM Herranz, MU Latasa… - Journal of …, 2023 - Elsevier
Background & Aims Hepatoblastoma (HB) is the most frequent childhood liver cancer.
Patients with aggressive tumors have limited therapeutic options; therefore, a better …
Patients with aggressive tumors have limited therapeutic options; therefore, a better …
Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type
I Franco, HT Helgadottir, A Moggio, M Larsson… - Genome biology, 2019 - Springer
Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …