The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …

Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to
respond rapidly upon infection or tissue damage, and in turn couple these responses with …

Background and Aims Hepatic macrophages can be activated by many factors such as gut‐
derived bacterial components and factors released from damaged hepatocytes …

Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid
antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells …

Background Adenosine inhibits the activation of most immune cells and platelets. Selective
adenosine A2A receptor (A2AR) agonists such as regadenoson (RA) reduce inflammation in …

Hepatic macrophages can be activated by many factors such as gut-derived bacterial
components and factors released from damaged hepatocytes. Macrophage polarization …

Natural killer T (NKT) cells operate distinctly different metabolic programming from CD4 T
cells, including a strict requirement for glutamine to regulate cell homeostasis. However, the …

Natural killer T (NKT) cells are innate-like lymphocytes that bridge the gap between the
innate and adaptive immune responses. Like innate immune cells, they have a mature …

It is now appreciated that a group of lymphoid lineage cells, collectively called innate-like
effector lymphocytes, have evolved to integrate information relayed by the innate sensory …

Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that express an invariant
T cell receptor (TCR), which recognizes glycolipid antigens presented on CD1d molecules …