Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged
heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular …

Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …

Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …

The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …

GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed
therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been …

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …

Zoonotic coronaviruses (CoVs) are substantial threats to global health, as exemplified by the
emergence of two severe acute respiratory syndrome CoVs (SARS-CoV and SARS-CoV-2) …

Stem cells are highly resistant to viral infection compared to their differentiated progeny;
however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian …