Antimicrobial peptides: an update on classifications and databases
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …
indispensable component of host defenses. They consist of predominantly short cationic …
Chemical syntheses of bioinspired and biomimetic polymers toward biobased materials
MS Ganewatta, Z Wang, C Tang - Nature Reviews Chemistry, 2021 - nature.com
The rich structures and hierarchical organizations in nature provide many sources of
inspiration for advanced material designs. We wish to recapitulate properties such as high …
inspiration for advanced material designs. We wish to recapitulate properties such as high …
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences
J Huang, Y Xu, Y Xue, Y Huang, X Li, X Chen… - Nature Biomedical …, 2023 - nature.com
Systematically identifying functional peptides is difficult owing to the vast combinatorial
space of peptide sequences. Here we report a machine-learning pipeline that mines the …
space of peptide sequences. Here we report a machine-learning pipeline that mines the …
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations
The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical
repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report …
repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report …
Development and challenges of antimicrobial peptides for therapeutic applications
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …
countless human lives, however, is seriously challenged by the quick emergence of …
Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?
MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …
[HTML][HTML] Focus: antimicrobial resistance: antimicrobial peptides therapy: an emerging alternative for treating drug-resistant bacteria
Microbial resistance to antibiotics is an ancient and dynamic issue that has brought a
situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance …
situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance …
Recent advances in short peptide self-assembly: from rational design to novel applications
Owing to their structural simplicity and robust self-assembled nanostructures, short peptides
prove to be an ideal system to explore the physical processes of self-assembly, hydrogels …
prove to be an ideal system to explore the physical processes of self-assembly, hydrogels …
Antimicrobial peptides as anti-infective agents in pre-post-antibiotic era?
Resistance to antibiotics is one of the main current threats to human health and every year
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …