Sending out an SOS-the bacterial DNA damage response
MA Lima-Noronha, DLH Fonseca… - … and molecular biology, 2022 - SciELO Brasil
The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put
together the data suggestive of a concerted gene expression program in cells undergoing …
together the data suggestive of a concerted gene expression program in cells undergoing …
From processivity to genome maintenance: the many roles of sliding clamps
Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …
of the replicative polymerase. They also serve as an interacting platform for a plethora of …
Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks …
Y Benureau, C Pouvelle, P Dupaigne… - Nucleic Acids …, 2022 - academic.oup.com
DNA lesions in S phase threaten genome stability. The DNA damage tolerance (DDT)
pathways overcome these obstacles and allow completion of DNA synthesis by the use of …
pathways overcome these obstacles and allow completion of DNA synthesis by the use of …
Single strand gap repair: the presynaptic phase plays a pivotal role in modulating lesion tolerance pathways
L Laureti, L Lee, G Philippin, M Kahi, V Pagès - PLoS Genetics, 2022 - journals.plos.org
During replication, the presence of unrepaired lesions results in the formation of single
stranded DNA (ssDNA) gaps that need to be repaired to preserve genome integrity and cell …
stranded DNA (ssDNA) gaps that need to be repaired to preserve genome integrity and cell …
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation
The bacterial SOS response plays a key role in adaptation to DNA damage, including
genomic stress caused by antibiotics. SOS induction begins when activated RecA*, an …
genomic stress caused by antibiotics. SOS induction begins when activated RecA*, an …
Tolerance of lesions in E. coli: chronological competition between translesion synthesis and damage avoidance
RP Fuchs - DNA repair, 2016 - Elsevier
Lesion tolerance pathways allow cells to proceed with replication despite the presence of
replication-blocking lesions in their genome. Following transient fork stalling, replication …
replication-blocking lesions in their genome. Following transient fork stalling, replication …
Homologous recombination maintenance of genome integrity during DNA damage tolerance
F Prado - Molecular & Cellular Oncology, 2014 - Taylor & Francis
The DNA strand exchange protein Rad51 provides a safe mechanism for the repair of DNA
breaks using the information of a homologous DNA template. Homologous recombination …
breaks using the information of a homologous DNA template. Homologous recombination …
Visualizing mutagenic repair: novel insights into bacterial translesion synthesis
AM Joseph, A Badrinarayanan - FEMS Microbiology Reviews, 2020 - academic.oup.com
ABSTRACT DNA repair is essential for cell survival. In all domains of life, error-prone and
error-free repair pathways ensure maintenance of genome integrity under stress. Mutagenic …
error-free repair pathways ensure maintenance of genome integrity under stress. Mutagenic …
A defect in homologous recombination leads to increased translesion synthesis in E. coli
DNA damage tolerance pathways allow cells to duplicate their genomes despite the
presence of replication blocking lesions. Cells possess two major tolerance strategies …
presence of replication blocking lesions. Cells possess two major tolerance strategies …
Bacterial proliferation: keep dividing and don't mind the gap
DNA Damage Tolerance (DDT) mechanisms help dealing with unrepaired DNA lesions that
block replication and challenge genome integrity. Previous in vitro studies showed that the …
block replication and challenge genome integrity. Previous in vitro studies showed that the …