Obstructive sleep apnea and the metabolic syndrome: the road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment

J Gaines, AN Vgontzas, J Fernandez-Mendoza… - Sleep medicine …, 2018 - Elsevier
Obstructive sleep apnea (OSA) is an increasingly prevalent sleep disorder characterized by
upper airway obstruction during sleep, resulting in breathing pauses, intermittent hypoxia …

Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches

AV Zinchuk, MJ Gentry, J Concato, HK Yaggi - Sleep medicine reviews, 2017 - Elsevier
Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea
hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …

Phenotypic subtypes of OSA: a challenge and opportunity for precision medicine

A Zinchuk, HK Yaggi - Chest, 2020 - Elsevier
Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

The association between sleep and metabolic syndrome: a systematic review and meta-analysis

T Che, C Yan, D Tian, X Zhang, X Liu… - Frontiers in …, 2021 - frontiersin.org
Purpose Sleep duration is thought to play a key role in the development of metabolic
syndrome. However, the results have been inconsistent. Methods We conducted a …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in patients with obstructive sleep apnea

BA Edwards, C Andara, S Landry… - American journal of …, 2016 - atsjournals.org
Rationale: Oral appliances (OAs) are commonly used as an alternative treatment to
continuous positive airway pressure for patients with obstructive sleep apnea (OSA) …

Evidence of neurodegeneration in obstructive sleep apnea: relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

MA Daulatzai - Journal of neuroscience research, 2015 - Wiley Online Library
The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late‐
onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly …

Understanding phenotypes of obstructive sleep apnea: applications in anesthesia, surgery, and perioperative medicine

Y Subramani, M Singh, J Wong, CA Kushida… - Anesthesia & …, 2017 - journals.lww.com
Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing with potential long-
term major neurocognitive and cardiovascular sequelae. The pathophysiology of OSA varies …

Sleep disturbance, sleep disorders and co-morbidities in the care of the older person

CE Mc Carthy - Medical Sciences, 2021 - mdpi.com
Sleep complaints can be both common and complex in the older patient. Their consideration
is an important aspect of holistic care, and may have an impact on quality of life, mortality …

A novel model to estimate key obstructive sleep apnea endotypes from standard polysomnography and clinical data and their contribution to obstructive sleep apnea …

R Dutta, G Delaney, B Toson, AS Jordan… - Annals of the …, 2021 - atsjournals.org
Rationale: There are at least four key pathophysiological endotypes that contribute to
obstructive sleep apnea (OSA) pathophysiology. These include 1) upper-airway …