The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

INTRODUCTION Activation of the STING (stimulator of interferon genes) protein by its
natural ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane
protein that is a target of therapeutics for infectious diseases and cancer. However, early …

Synthetic biology is a powerful tool to create therapeutics which can be rationally designed
to enable unique and combinatorial functionalities. Here we utilize non-pathogenic E coli …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have
been effective in only a small subset of patients and a principal mechanism underlying …

Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet
factors dictating the balance between innate and adaptive anti-tumor immunity are unclear …

The rapid detection of microbial agents is essential for the effective initiation of host defence
mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger …