Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

The inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Redox signaling refers to the specific and usually reversible oxidation/reduction modification
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …