Pain is a common symptom induced during envenomation by spiders and scorpions. Toxins
isolated from their venom have become essential tools for studying the functioning and …

Although necessary for human survival, pain may sometimes become pathologic if long-
lasting and associated with alterations in its signaling pathway. Opioid painkillers are …

Fibroblast growth factor homologous factors (FHFs) are cytosolic members of the
superfamily of the FGF proteins. Four members of this subfamily (FHF1–4) are differentially …

Sensory neurons respond to noxious stimuli by relaying information from the periphery to the
central nervous system via action potentials driven by voltage-gated sodium channels …

Burn injuries can be devastating, with life-long impacts including an increased risk of
hospitalization for a wide range of secondary morbidities. One area that remains not fully …

Background and Purpose Protoxin II (ProTx II) is a high affinity gating modifier that is thought
to selectively block the Nav1. 7 voltage‐dependent Na+ channel, a major therapeutic target …

Burn injury can be a devastating traumatic injury, with long-term personal and social
implications for the patient. The many complex local and disseminating pathological …

The role of the voltage‐gated sodium channel 1.7 (Nav1. 7) is unclear in models of
neuropathic pain induced by nerve injury. In the present study, we measured expression …

Ion channels play critical roles in generating and propagating action potentials and in
neurotransmitter release at a subset of excitatory and inhibitory synapses. Dysfunction of …

疼痛普遍存在于人类与多种动物中, 其机制较为复杂, 并影响广泛. 目前的疗法通常无法达到预期
的疗效和耐受性, 因此疼痛的有效治疗仍然是一个挑战. 对离子通道信号转导的调节 …