Inhaled proteins: challenges and perspectives

F Depreter, G Pilcer, K Amighi - International journal of pharmaceutics, 2013 - Elsevier
Due to recent developments in biochemical engineering and in the understanding of the
physiopathology of many diseases, therapeutic biologics are expected to become of …

Towards tailored vaccine delivery: needs, challenges and perspectives

JP Amorij, GFA Kersten, V Saluja, WF Tonnis… - Journal of Controlled …, 2012 - Elsevier
The ideal vaccine is a simple and stable formulation which can be conveniently
administered and provides life-long immunity against a given pathogen. The development of …

Stabilization of HAC1 influenza vaccine by spray drying: formulation development and process scale-up

C Zhu, Y Shoji, S McCray, M Burke, CE Hartman… - Pharmaceutical …, 2014 - Springer
Purpose Stable vaccines with long shelf lives and reduced dependency on the cold chain
are ideal for stockpiling and rapid deployment during public emergencies, including …

Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent system

R Correia, L Meneses, C Richheimer, PM Alves… - Vaccine, 2021 - Elsevier
Vaccines are typically stored under refrigerated conditions (2–8° C) to limit potency and
efficacy loss. Maintaining the cold chain is costly and prone to vaccine wastage due to …

[图书][B] Advances in pulmonary drug delivery

PCL Kwok, HK Chan - 2016 - taylorfrancis.com
The respiratory tract has been used to deliver biologically active chemicals into the human
body for centuries. However, the lungs are complex in their anatomy and physiology, which …

[引用][C] Water-free liquid systems for enhancing stability of next generation Influenza vaccines

CMR Richheimer - 2019