Quantitative approaches to guide epilepsy surgery from intracranial EEG

JM Bernabei, A Li, AY Revell, RJ Smith… - Brain, 2023 - academic.oup.com
Over the past 10 years, the drive to improve outcomes from epilepsy surgery has stimulated
widespread interest in methods to quantitatively guide epilepsy surgery from intracranial …

Modulation of human memory by deep brain stimulation of the entorhinal-hippocampal circuitry

EA Mankin, I Fried - Neuron, 2020 - cell.com
Neurological disorders affecting human memory present a major scientific, medical, and
societal challenge. Direct or indirect deep brain stimulation (DBS) of the entorhinal …

Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans

M Geva-Sagiv, EA Mankin, D Eliashiv, S Epstein… - Nature …, 2023 - nature.com
Memory consolidation during sleep is thought to depend on the coordinated interplay
between cortical slow waves, thalamocortical sleep spindles and hippocampal ripples, but …

DBS of thalamic centromedian nucleus for Lennox–Gastaut syndrome (ESTEL trial)

LJ Dalic, AEL Warren, KJ Bulluss… - Annals of …, 2022 - Wiley Online Library
Objective Prior uncontrolled studies have reported seizure reductions following deep brain
stimulation (DBS) in patients with Lennox–Gastaut syndrome (LGS), but evidence from …

Intrinsic network architecture predicts the effects elicited by intracranial electrical stimulation of the human brain

KCR Fox, L Shi, S Baek, O Raccah, BL Foster… - Nature human …, 2020 - nature.com
Intracranial electrical stimulation (iES) of the human brain has long been known to elicit a
remarkable variety of perceptual, motor and cognitive effects, but the functional–anatomical …

Does the prefrontal cortex play an essential role in consciousness? Insights from intracranial electrical stimulation of the human brain

O Raccah, N Block, KCR Fox - Journal of Neuroscience, 2021 - Soc Neuroscience
A central debate in philosophy and neuroscience pertains to whether PFC activity plays an
essential role in the neural basis of consciousness. Neuroimaging and electrophysiology …

Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model

BJG van den Boom, A Elhazaz-Fernandez… - Nature …, 2023 - nature.com
Deep-brain stimulation (DBS) is an effective treatment for patients suffering from otherwise
therapy-resistant psychiatric disorders, including obsessive-compulsive disorder …

Neuronal activity in the human amygdala and hippocampus enhances emotional memory encoding

SE Qasim, UR Mohan, JM Stein, J Jacobs - Nature Human Behaviour, 2023 - nature.com
Emotional events comprise our strongest and most valuable memories. Here we examined
how the brain prioritizes emotional information for storage using direct brain recording and …

Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters

AC Paulk, R Zelmann, B Crocker, AS Widge… - Brain stimulation, 2022 - Elsevier
Background Electrical neuromodulation via direct electrical stimulation (DES) is an
increasingly common therapy for a wide variety of neuropsychiatric diseases. Unfortunately …

Closed-loop neurostimulation for the treatment of psychiatric disorders

KK Sellers, JL Cohen, AN Khambhati, JM Fan… - …, 2024 - nature.com
Despite increasing prevalence and huge personal and societal burden, psychiatric diseases
still lack treatments which can control symptoms for a large fraction of patients. Increasing …