Licorice (Glycyrrhiza glabra) is a well-known natural herb used to treat different ailments
since ancient times. Glycyrrhizin (GL), which is the primary triterpenoid compound of licorice …

In 1971, Folkman proposed that tumors could be limited to very small sizes by blocking
angiogenesis. Angiogenesis is the generation of new blood vessels from pre-existing …

Background As one of the most classic antineoplastic agents, doxorubicin (Dox) is
extensively used to treat a wide range of cancers. Nevertheless, the clinical outcomes of Dox …

A glycyrrhetinic acid-modified carboxymethyl chitosan-thioketal-rhein (GCTR) conjugate was
designed and synthesized for the in vivo delivery of celastrol (Cela). Cela was encapsulated …

Background Breast cancer metastasis is leading cause of cancer death among women
worldwide. Tumor-associated macrophages (TAMs) have been considered as potential …

Background Therapeutic regimens of breast cancer treatment are increasingly inclined to
adopt combination strategy based on the broad spectrum antitumor effect of doxorubicin …

Ethnopharmacological relevance As a" silent killer" that threatens women's lives and health,
ovarian cancer (OC) has the clinical characteristics of being difficult to detect, difficult to treat …

Clinical outcomes for doxorubicin (Dox) are limited by its cardiotoxicity but a combination of
Dox and agents with cardioprotective activities is an effective strategy to improve its …

Despite various therapeutic approaches, colorectal cancer is among the most fatal diseases
globally. Hence, developing novel and more effective methods for colorectal cancer …

Background: The anti-cancer activity of andrographolide (Andro) has been extensively
demonstrated in recent years. It is supposed that modifying the chemical structure of Andro …