Proteins recognizing DNA: Structural uniqueness and versatility of DNA-binding domains in stem cell transcription factors
Proteins in the form of transcription factors (TFs) bind to specific DNA sites that regulate cell
growth, differentiation, and cell development. The interactions between proteins and DNA …
growth, differentiation, and cell development. The interactions between proteins and DNA …
In silico identification of natural product inhibitors against Octamer-binding transcription factor 4 (Oct4) to impede the mechanism of glioma stem cells
C Nayak, SK Singh - Plos one, 2021 - journals.plos.org
Octamer-binding transcription factor 4 (Oct4) is a core regulator in the retention of stemness,
invasive, and self-renewal properties in glioma initiating cells (GSCs) and its overexpression …
invasive, and self-renewal properties in glioma initiating cells (GSCs) and its overexpression …
Evaluation of Sox2 binding affinities for distinct DNA patterns using steered molecular dynamics simulation
Transcription factors (TF s) are gene expression regulators that bind to DNA in a sequence‐
specific manner and determine the functional characteristics of the gene. It is worthwhile to …
specific manner and determine the functional characteristics of the gene. It is worthwhile to …
Structural mechanism of DNA-mediated Nanog–Sox2 cooperative interaction
The efficiency of stem cell transcriptional regulation always depends on the cooperative
association and expression of transcription factors (TFs). Among these, Oct4, Sox2, and …
association and expression of transcription factors (TFs). Among these, Oct4, Sox2, and …